Research states that more than 5 million Americans are affected by Alzheimer's disease. This number is going to increase by 7 million by 2030. Alzheimer's disease is an age-associated, irreversible, progressive neurodegenerative disease that is characterized by severe memory loss, unusual behavior, personality changes, and a decline in cognitive function. No cure for Alzheimer's exists, and the drugs currently available to treat the disease have limited effectiveness. It is believed that therapeutic intervention that could postpone the onset or progression of Alzheimer's disease would dramatically reduce the number of cases in the next 50 years.
The underlying pathogenesis is loss of neurons in the hippocampus, cortex, and subcortical structures. Early disease shows a loss of short-term memory, inability to learn new information, mood swings, difficulty in finding words, forgetting names, and losing items.